投稿分類 其他

主委發表種類: 壁報

投稿標題(中): 住院成人適時使用益生菌是否能預防困難梭狀桿菌感染

投稿標題(英): Could The Use of Probiotics Timely in Hospitalized Adults Prevent Clostridium difficile Infection?

投稿摘要: Purpose: The incidence of C. difficile infection (CDI) is increasing and a health threat in Taiwan. We applied EBM methods to search meta-analyzed evidence. Methods: The keyword: (Hospitalized Adult*) AND Probiotics AND (Clostridium difficile) was used to search PubMed. We filtered 3 relevant SR. One latest, 2017 published SR was selected for critical appraisal. Results: The incidence of CDI= 1.6%, was lower than of controls= 3.9% (P ＜ 0.001). The pooled relative risk (RR) of CDI in probiotic users was 0.42 (95% CI 0.30- 0.57; I2 = 0.0%). Probiotics were significantly more effective if given closer to the first antibiotic dose, with a decrement in efficacy for every day of delay in starting probiotics (P = 0.04). Conclusions: We found evidence that administration of probiotics closer to the first dose of antibiotic reduces the risk of CDI by ＞50% in hospitalized adults. In caring for patients with CDI, the Use of probiotics is a very effective and cost saving preventive strategy.

稿件檔: