投稿分類 抗生素管制

主委發表種類: 壁報

投稿標題(中): 某醫院2005年至2010年醫療照護相關感染之CRAB與抗生素消耗量相互關係

投稿標題(英): Correlation between antibiotic consumption and carbapenem resistant Acinetobacter baumannii causing healthcare-associated infections at a hospital from 2005 to 2010

投稿摘要: Objectives: This study investigated the correlation between antibiotic consumption and the incidence of HCAI caused by CRAB at a hospital in Taiwan from 2005 to 2010.Methods: Data on annual consumption (DDD per 1000 patient-days) of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, carbapenems, aminoglycosides, and fluoroquinolones from 2005 to 2010 were analyzed. Yearly aggregated data on the number of non-duplicate clinical CRAB isolates causing HCAI were collected. The incidence rates of HCAI-CRAB were defined as the number of patients with HCAI CRAB per 1,000 inpatient-days.
Results: Overall, the trend of total consumption (DDD per 1000 patient-days) of extended-spectrum cephalosporins, carbapenems, and fluoroquinolones significantly increased, but the use of aminoglycosides decreased during 2005 to 2010 (table 1). In the meanwhile, the incidence of HCAI- CRAB gradually increases (figure 1). Although there was no significant association between the uses of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, aminoglycosides and the incidence of HCAI-CRAB, the consumptions of carbapenems, and fluroquinolones were positively correlated with the incidence of HCAI-CRAB (table 2).Conclusions: This study showed that the consumptions of most of the antibiotic, except aminoglycoside, significantly increased during this 6-year study in an institution. As well as the increasing use of carbapenem and fluoroquinolones, the incidence of HCAI-CRAB is increasing.

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